Anesthetic monitoring of the thiopental-propofol mixture in canine females during ovariohysterectomy

Abstract

Objective: to monitor the final expiratory fraction of CO2 (capnometry), oxygen saturation in hemoglobin (pulse oximetry) and non-invasive mean arterial pressure (MAP) in healthy dogs during ovariohysterectomy (OVH), in which anesthesia was induced and maintained with the Propofol-Thiopental (PT) mixture. Materials and methods: Pre-surgical analysis was performed. The premedication included acepromazine, ketoprofen and tramadol, the anesthetic induction was performed with a mixture in equal parts of propofol 10% and thiopental 2.5%. The induction dose was calculated based on the thiopental present in each cm3 of the mixture, and was 3 mg / kg of thiopental / IV. Bowls were given for the effect of 1 mg / kg of thiopental present in the mixture for maintenance. Capnometry, pulse oximetry and MAP were measured every five minutes using a multiparametric monitor. The data were analyzed with an inferential study aimed at finding a confidence interval for the mean oxygen saturation in hemoglobin (SO2), final expiratory fraction of CO2 (FEFCO2) and PAM, with a confidence level of 95%. Results: SO2 maintained an average of 97%, MAP was throughout the intervention above 60 mmHg, FEFCO2 was initially high> 45mmHg, but return to normal values after 25 minutes. On average there was no hypoxia or hypotension, but mild hypercapnia at the beginning. Conclusion: For the three variables studied, the P-T mixture was safe. Studies with broader monitoring are suggested to determine hemodynamic and respiratory safety.