Effects of picrotoxin administration on sexual behavior of male rats

Authors

  • M. R. P SILVA University of São Paulo, São Paulo, SP, Brazil
  • P.E. CRUZ-CASALLAS University of the Llanos, Villavicencio, Meta, Colombia
  • L.F FELÍCIO University of São Paulo, São Paulo, SP, Brazil
  • M.M. BERNARDI University of São Paulo, São Paulo, SP, Brazil

DOI:

https://doi.org/10.22579/20112629.135

Keywords:

GABA, male sexual behavior, picrotoxin, sexual stimulation, sexual inhibition

Abstract

Titulo en español: Efectos de la administración de picrotoxin sobre el comportamiento sexual en ratas  machos.

ABSTRACT: The effects of several doses of picrotoxin  on sexual behavior of inexperienced male rats  were examined. The lowest doses tested  (0.5 and 0.75  mg kg-1) did not alter  the sexual behavioral parameters, whereas the  higher doses (1.5 and 2.0 mg kg-1) increased latencies for the first mount and intromission and reduced the number of mounts and intromissions and the total number of mounts. None of the picrotoxin doses significantly modified the mount frequency or the copulatory efficiency. The sexual activity index decreased after  administration of 1.5 and 2.0 mg kg-1 picrotoxin. The inhibitory effects of the larger doses of picrotoxin on male sexual behavior may be a consequence of both a drug interference with motor function and a dose-dependent picrotoxin-induced stress influence.

Key words: GABA, male sexual behavior, picrotoxin, sexual stimulation, sexual inhibition.

RESUMEN: Fueron evaluados los efectos de varias dosis de picrotoxina sobre el comportamiento sexual de ratas macho. La dosis más baja (0.5 mg kg-1) no alteró, la dosis intermedia (0.75mg kg-1) facilitó algunas de las variables del comportamiento sexual (disminuyó las latencias para la primera monta, primera intromisión y eyaculación), mientras que las dosis más altas (1.5 and 2.0 mg kg-1) aumentaron las latencias para  la primera monta e intromisión y redujeron el número total de montas e intromisiones.  Ninguna de las dosis de picrotoxina estudiadas modificó significativamente la frecuencia de monta o la eficiencia copulatoria. El índice de actividad sexual disminuyó después de la administración de 1.5 o 2.0mg kg-1 de picrotoxina. Los efectos inhibitorios de las dosis más altas de picrotoxina sobre el comportamiento sexual de los machos  pueden ser consecuencia, tanto de la interferencia con la función motora como de la influencia del estrés inducido por la picrotoxina.

Palabras Clave:  GABA, comportamiento sexual masculino, picrotoxina, estimulación sexual, inhibición sexual

Downloads

Download data is not yet available.

Author Biographies

  • M. R. P SILVA, University of São Paulo, São Paulo, SP, Brazil
    Department of Pathology, Faculty of Veterinary Medicine  and Zootechny, University of São Paulo, São Paulo, SP, Brazil
  • P.E. CRUZ-CASALLAS, University of the Llanos, Villavicencio, Meta, Colombia
    School of Veterinary Medicine  and Zootechny, University of the Llanos, Villavicencio, Meta, Colombia
  • L.F FELÍCIO, University of São Paulo, São Paulo, SP, Brazil
    Department of Pathology, Faculty of Veterinary Medicine  and Zootechny, University of São Paulo, São Paulo, SP, Brazil
  • M.M. BERNARDI, University of São Paulo, São Paulo, SP, Brazil
    Av. Prof.  Dr. Orlando Marques de Paiva, 87 São Paulo, SP, CEP: 05508-900.  Brasil Department of Pathology, Faculty of Veterinary Medicine  and Zootechny, University of São Paulo, São Paulo, SP, Brazil. Author to whom correspondence should be addressed:  Dra. Maria  Martha Bernardi,

References

Downloads

Published

2008-09-01

Issue

Vol. 9 No. 2 (2005)

Section

Articles

How to Cite

Effects of picrotoxin administration on sexual behavior of male rats. (2008). Orinoquia, 9(2), 22-27. https://doi.org/10.22579/20112629.135

Similar Articles

1-10 of 29

You may also start an advanced similarity search for this article.

Most read articles by the same author(s)